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Polycystic kidney disease (PKD) is the most common inherited kidney disease affecting one in 800 people. It is passed down from parent to child over generations, through classic Mendelian genetics. There have been several advances in our understanding of PKD since our last blog. This blog will discuss the genetics of PKD. In the next…
Kidney stone formation is a complex disorder influenced by multiple factors including diet, genetics, and environment, as reviewed in our earlier blogs. Kidney stones are painful, inconvenient, and when left untreated, they may contribute to more serious conditions including obstruction and kidney damage. The gut also plays an important role in kidney health and is…
Genetic testing for patients with kidney disease can have a remarkable impact on their care. In this blog, we will focus on the clinical utility of genetic testing for kidney transplant evaluation.
Genetics are one factor that plays a significant role in the development of kidney disease. Genome-wide association studies (GWAS) have identified several hundred genes that are associated with kidney diseases. Therefore, genetic testing may play a crucial role in the management of kidney disease patients.
Current evidence suggests that genetics play a role in the development of kidney disease. Common genetic disorders associated with kidney disease include polycystic kidney disease, Alport’s Syndrome and Fabry’s disease. In this blog, we will detail the benefits of broad-panel genetic testing in kidney disease management.
This blog is an intro into a series of blogs discussing the genetics of chronic kidney disease (CKD). A significant advance in kidney disease
Kidney stone development is the composite end-result of multiple factors including genetic, dietary and environmental, and can have serious consequences. They are often painful and if left unaddressed can lead to more severe conditions such as obstruction of urinary flow and permanent damage to the kidneys. Recurrent kidney stones are one of the common causes…
According to a report by the US Food and Drug Administration (FDA), 2.2 million adverse drug reactions (ADRs) occur in the US annually. On the other hand, the healthcare cost and morbidity associated with ineffective medication cause unnecessary burdens as well as patient confidence in treatment. Clinicians continuously strive to strike a balance between medication choices…
This is a beginning of a series of blogs that explores the emerging view regarding the genetic risk of kidney disease. Consider this series your crash course in epigenetics! But before we dive in, let’s start with a refresher on genetics. By Lara Zakaria, PharmD, CNS, CDN, IFMCP You may remember from your high school…